Related Experiment Video
Updated: Jul 30, 2025

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
[Cost-effectiveness of treatment of type 2 diabetes mellitus in México]
Diana L Pérez-Lozano1, Víctor Manuel Camarillo-Nava2, Tarsila Elizabeth Juárez-Zepeda3
1Universidad Autónoma de México, Programa de Maestría y Doctorado en Ciencias Médicas y Odontológicas y de la Salud, Unidad de posgrado. Ciudad de México, México.
Background:
Type 2 Diabetes Mellitus (DM2) is a public health and socioeconomic problem, generating direct medical costs for its treatment.
Objective:
To analyze the cost-effectiveness of monotherapy and bitherapy treatments in patients with DM2.
Methods:
Cost-effectiveness, observational, ambispective, cross-sectional and analytical analysis of files in a first level medical unit. The data in the cost matrix was executed with the Office Excel 2010 program; the most prescribed drug was identified and compared with monotherapy and bitherapy.
Results:
The annual direct medical costs of the total population were drug cost $118,561.70MN, hospitalization cost $243,756.00MN, consultation cost $327,414.00MN and clinical trial cost $2416.79MN, obtaining an annual total of $692,148.58MN. metformin was the most indicated in monotherapy (88.4%) and as standard therapy it has higher cost-effectiveness compared to glibenclamide. In bitherapy it was metformin/glibenclamide (35.7%) versus the therapeutics of metformin/NPH insulin, metformin/insulin glargine and metformin/dapagliflozin, which had a better cost-effective result, with an incremental cost effectiveness of -$1,128,428.50MN, -$34,365.00 MN, -$119,848.97MN respectively.
Conclusions:
Metformin presented a better cost-effectiveness ratio in monotherapy, while in bitherapy it was the metformin/NPH insulin association.
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