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Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Cancer In Patients With Familial Adenomatous Polyposis: A Nationwide Danish Cohort Study With Matched Controls.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Cancer In Patients With Familial Adenomatous Polyposis: A Nationwide Danish Cohort Study With Matched Controls.

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Cancer in Patients With Familial Adenomatous Polyposis: A Nationwide Danish Cohort Study With Matched Controls.

John Gásdal Karstensen1, Steffen Bülow2, Helle Højen2

  • 1Danish Polyposis Register, Gastro Unit, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Gastroenterology
|May 18, 2023

View abstract on PubMed

Summary
This summary is machine-generated.

Patients with familial adenomatous polyposis (FAP) have a higher risk of colorectal, pancreatic, and small-bowel cancers. Despite a 50% reduction in cancer risk since 1980, FAP patients still face elevated risks compared to the general population.

Keywords:
Adenomatous Polyposis Coli GeneColorectal CancerFamilial Adenomatous PolyposisGastric Cancer

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Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • Familial adenomatous polyposis (FAP) is an inherited condition increasing colorectal cancer (CRC) risk.
  • While prophylactic colectomy reduces CRC, FAP is linked to other cancer risks.
  • This study investigates FAP's association with primary and secondary cancer risks.

Purpose of the Study:

  • To assess the risk of specific primary and secondary cancers in FAP patients compared to matched controls.
  • To quantify the cancer risk associated with FAP, considering various cancer types.

Main Methods:

  • Utilized the Danish Polyposis Register to identify FAP patients up to April 2021.
  • Matched each FAP patient with four controls based on birth year, sex, and postal code.
  • Analyzed overall cancer risk, specific cancer types, and second primary cancer risk.
Pancreatic Cancer

Main Results:

  • Included 565 FAP patients and 1890 controls.
  • FAP patients had a 4.12-fold higher overall cancer risk (P < .001).
  • Significantly increased risks observed for colorectal (HR 4.61), pancreatic (HR 6.45), and duodenal/small-bowel cancers (HR 14.49).
  • FAP patients had a 1.89-fold higher risk of a second primary cancer (P = .042).
  • Cancer risk in FAP patients decreased by approximately 50% between 1980 and 2020.

Conclusions:

  • FAP patients face a persistently higher cancer risk, particularly for colorectal, pancreatic, and duodenal/small-bowel cancers.
  • Despite risk reductions, vigilance for these cancers in FAP patients remains crucial.
  • The study highlights the importance of ongoing monitoring and management for FAP-associated cancers.