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p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis

Chiharu Uchida1, Hiroyuki Niida2, Satoshi Sakai2

  • 1Advanced Research Facilities & Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.

Biochimica Et Biophysica Acta. Molecular Cell Research
|May 18, 2023
PubMed
Summary

p130RB2 protein is essential for activating Ataxia-telangiectasia mutated and Rad3-related (ATR) kinase during DNA replication stress. Its absence disrupts cell cycle progression and survival, highlighting its role in maintaining genome integrity.

Keywords:
ATR activationETAA1Replication stressp130RB2

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