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Melatonin supplementation improves rheumatological disease activity: A systematic review
Jozélio Freire de Carvalho1, Thelma L Skare2
1Núcleo de Pesquisa Em Doenças Crônicas Não Transmissíveis (NUPEN), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.
Clinical Nutrition ESPEN
|May 18, 2023
Summary
Melatonin supplementation shows promise for certain rheumatic conditions like fibromyalgia and osteoarthritis, with good tolerability. Further research is needed to confirm its role in rheumatology.
Area of Science:
- Rheumatology
- Endocrinology
- Pharmacology
Background:
- Melatonin, a pineal hormone, influences sleep, inflammation, immunity, and oxidative processes.
- Rheumatic diseases encompass a range of conditions affecting joints, muscles, and connective tissues.
Approach:
- A systematic literature review was conducted using PubMed, Embase, and Scielo databases.
- Searched for studies on melatonin and rheumatic diseases published from 1966 to August 2022.
Key Points:
- Thirteen articles were analyzed, covering fibromyalgia, rheumatoid arthritis, systemic sclerosis, lupus erythematosus, osteoporosis/osteopenia, and osteoarthritis.
- Positive outcomes were observed for melatonin in fibromyalgia, osteoarthritis, and osteoporosis/osteopenia.
- Melatonin was not effective in rheumatoid arthritis and lupus, and was generally well-tolerated with minor side effects.
Conclusions:
- Melatonin demonstrates efficacy in managing specific rheumatic diseases.
- Additional research is required to fully understand melatonin's therapeutic potential in rheumatology.
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