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Related Experiment Video

Updated: Jul 30, 2025

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
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Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

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Subarachnoid Space Measurements in Apparently Healthy Fetuses Using MR Imaging.

A Wandel1,2, T Weissbach3,4, E Katorza3,4,5

  • 1From the Sackler School of Medicine (A.W., T.W., E.K.) ayeletwandel@yahoo.com.

AJNR. American Journal of Neuroradiology
|May 18, 2023
PubMed
Summary
This summary is machine-generated.

This study establishes normal ranges for fetal subarachnoid space size using MR imaging. These reproducible measurements aid in assessing fetal brain development and support clinical decision-making.

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Area of Science:

  • Neuroimaging
  • Fetal Development
  • Radiology

Background:

  • Fetal subarachnoid space size is a key indicator of normal brain development.
  • Ultrasound is commonly used for measurement, but MR imaging offers improved standardization and accuracy.
  • Advancements in fetal brain evaluation necessitate standardized MR imaging parameters.

Purpose of the Study:

  • To determine the normal range of fetal subarachnoid space size using MR imaging.
  • To establish reference values correlated with gestational age.
  • To enhance the accuracy of fetal brain development assessment.

Main Methods:

  • Retrospective cross-sectional study of 214 healthy fetal brain MR images (2012-2020).
  • Measurements taken at 10 reference points in axial and coronal planes for scans between 28-37 weeks gestation.
  • Exclusion criteria included low-quality scans, multiple pregnancies, and intracranial abnormalities.

Main Results:

  • 214 fetuses included; mean maternal age 31.2 years.
  • High interobserver and intraobserver agreement (ICC > 0.75) for measurements.
  • Percentiles (3rd, 15th, 50th, 85th, 97th) for subarachnoid space size were described for each gestational week.

Conclusions:

  • MR imaging provides reproducible fetal subarachnoid space measurements due to high resolution and precise plane adherence.
  • Established normal MR imaging values serve as crucial reference data for fetal brain development assessment.
  • These findings are valuable for both clinicians and parents in decision-making processes.