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Updated: Jun 8, 2026
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
16.6K
Guidelines for genetic testing in prostate cancer: a scoping review
Haitham Tuffaha1, Kim Edmunds2, David Fairbairn3
1Centre for the Business and Economics of Health, University of Queensland, Brisbane, QLD, Australia. h.tuffaha@uq.edu.au.
Prostate Cancer and Prostatic Diseases
|May 18, 2023
Summary
Genetic testing for prostate cancer is recommended, but guidelines lack consensus on who should be tested and how. Further evidence is needed for effective genetic testing strategies in clinical practice.
Area of Science:
- Oncology
- Genetics
- Medical Guidelines
Background:
- Genetic testing identifies pathogenic variants in prostate cancer, guiding treatment and informing relatives.
- Existing guidelines and consensus statements address genetic testing in prostate cancer.
- The level of evidence supporting these recommendations requires review.
Purpose of the Study:
- To review genetic testing recommendations across current guidelines and consensus statements for prostate cancer.
- To assess the evidence supporting these genetic testing recommendations.
Main Methods:
- A scoping review was conducted following PRISMA-ScR guidelines.
- Searches included electronic databases and grey literature from key organizations.
- The review included men with prostate cancer, high-risk individuals, their families, and relevant guidelines/consensus statements.
Main Results:
- 23 guidelines and consensus statements met inclusion criteria from 660 citations.
- General consensus exists for testing men with metastatic prostate cancer.
- Less consensus was found for localized prostate cancer regarding who to test, genes, methods, and implementation.
Conclusions:
- Despite routine recommendations, significant lack of consensus exists on prostate cancer genetic testing criteria and methods.
- Further evidence is required to develop value-based genetic testing strategies for practical implementation.
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