Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.9K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.9K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

1.1K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.1K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

1.3K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.3K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.2K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.2K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

853
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
853

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic alterations in the irradiated draining lymph node.

NPJ precision oncology·2026
Same author

Myocardial Immune Niches in Homeostasis and Inflammation.

Immunological reviews·2026
Same author

Convergence and divergence of DNA methylation and gene expression patterns in neopolyploid Arabidopsis kamchatica.

Nature communications·2026
Same author

Cleavage of MEP-1 by DPF-3 reveals novel substrate specificity and its impact on reproductive fitness.

EMBO reports·2026
Same author

FAP-CD40 and PD1-IL2v combination therapy reprograms immunologically cold tumors through de novo intratumoral T cell-dendritic cell clusters.

Journal for immunotherapy of cancer·2026
Same author

Resolving Sialylated N-Glycans and Immune Cell Landscapes Using a Unified Same-Section IMC-MSI Workflow.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jul 30, 2025

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.4K

Conserved stromal-immune cell circuits secure B cell homeostasis and function.

Mechthild Lütge1, Angelina De Martin1, Cristina Gil-Cruz1

  • 1Institute of Immunobiology, Kantonsspital St.Gallen, St. Gallen, Switzerland.

Nature Immunology
|May 18, 2023
PubMed
Summary

B cell zone reticular cells (BRCs) create essential microenvironments for humoral immunity. Immune cell signals drive BRC development and function, ensuring effective immune responses across species.

More Related Videos

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.1K
Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion STED Microscopy
11:00

Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion STED Microscopy

Published on: April 9, 2018

13.9K

Related Experiment Videos

Last Updated: Jul 30, 2025

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.4K
Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.1K
Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion STED Microscopy
11:00

Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion STED Microscopy

Published on: April 9, 2018

13.9K

Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • B cell zone reticular cells (BRCs) are crucial for establishing microenvironments that support B cell priming and memory.
  • A comprehensive understanding of systemic humoral immunity requires knowledge of BRC sustenance, function, and interactions with immune cells.

Purpose of the Study:

  • To dissect the BRC landscape and immune cell interactome in human and murine lymphoid organs.
  • To identify key pathways controlling BRC-immune cell interactions and BRC functional niches.

Main Methods:

  • Analysis of BRC subsets and immune cell interactions in human and murine lymphoid tissues.
  • Investigated BRC differentiation and activation programs influenced by immune cell cues.

Main Results:

  • Identified PI16+ RCs as a BRC subset present across organs and species, in addition to follicular dendritic cells.
  • Demonstrated that immune cell-derived signals drive BRC differentiation and activation, leading to shared BRC subsets.
  • Revealed bidirectional signaling programs that sustain functional BRC niches across lymphoid organs and species.

Conclusions:

  • A conserved set of immune cell cues maintains functional BRC niches, essential for robust humoral immunity.
  • Understanding these BRC-immune cell interactions provides insights into maintaining efficient immune responses.