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Infective endocarditis due to penicillin-tolerant Streptococcus bovis
Diagnostic Microbiology and Infectious Disease
|July 1, 1986
Summary
Tolerant Streptococcus bovis strains, identified in endocarditis patients, resist penicillin. Combining penicillin with streptomycin shows synergistic effects, offering a potential treatment strategy for serious infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Streptococcus bovis is a significant cause of infective endocarditis.
- Penicillin and other cell wall active agents are standard treatments for S. bovis endocarditis.
Observation:
- Two S. bovis isolates from endocarditis patients exhibited tolerance to penicillin.
- Time-kill kinetic analysis was employed to assess antibiotic activity.
Findings:
- Penicillin tolerance was observed in the S. bovis isolates.
- Penicillin and streptomycin demonstrated synergistic activity against these tolerant strains.
Implications:
- The presence of tolerant S. bovis strains necessitates careful antibiotic selection for endocarditis treatment.
- Combination therapy, such as penicillin and streptomycin, may be crucial for effectively managing infections caused by tolerant S. bovis.