Sensitizing capacity of dihydroxydiphenyl methane (bisphenol F) in the guinea pig

The sensitizing capacity of 2,2(1)-dihydroxydiphenyl methane (2,2(1)-HPM), 4,4(1)-dihydroxydiphenyl methane (4,4(1)-HPM) and 2,4(1)-dihydroxydiphenyl methane (2,4(1)-HPM) was investigated with the guinea pig maximization test. These compounds are known contact sensitizers in phenol-formaldehyde resins. The study was performed to assess and compare their sensitizing capacities. A weak sensitizing capacity of 2,2(1)-HPM was demonstrated when the results for 2 separate series were added, while no sensitizing capacity was demonstrated for 4,4(1)-HPM or 2,4(1)-HPM. The compounds tested were chromatographically pure.