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Updated: Jul 28, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Outcomes of accelerated collagen cross linking in progressive paediatric keratoconus
B Preethi1, K Kiran Kumar2, G Suresh Babu2
1Department of Ophthalmology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research Harohalli, Kanakapura, Karnataka, India.
Insights
Accelerated corneal cross-linking (CXL) is effective for treating pediatric keratoconus (KC). This study found significant improvements in vision and corneal shape, demonstrating CXL
Area of Science:
- Ophthalmology
- Corneal Surgery
- Pediatric Eye Care
Background:
- Keratoconus (KC) is a progressive corneal disease affecting young patients.
- Early intervention is crucial to prevent vision loss in pediatric KC.
- Corneal cross-linking (CXL) aims to halt KC progression.
Purpose of the Study:
- To evaluate the efficacy and safety of accelerated corneal cross-linking (CXL) in children and adolescents (≤18 years).
- To assess the impact of accelerated CXL on visual acuity, refraction, and corneal topography in pediatric KC patients.
Main Methods:
- Prospective study involving 64 eyes of 39 pediatric KC patients.
- Epithelium-off accelerated CXL protocol administered.
- Regular follow-ups included visual acuity, slit-lamp examination, refraction, and Pentacam measurements for 12 months.
Main Results:
- Significant improvements observed in aided visual acuity, keratometry (K), and corneal astigmatism (p < 0.0001).
- Mean maximum keratometry (Kmax) reduced from 55.5 D to 54.41 D at 12 months post-procedure.
- Two cases showed progression; complications included sterile infiltrate and persistent haze.
Conclusions:
- Accelerated CXL is an effective and safe treatment option for pediatric progressive keratoconus.
- The procedure demonstrates positive outcomes in stabilizing and improving corneal parameters in young KC patients.
Purpose:
To determine the efficacy and safety of pediatric accelerated cross linking (CXL).
Methods:
A prospective study on progressive keratoconus (KC) cases under ≤18 years of age. Sixty four eyes of thirty nine cases underwent epithelium-off accelerated CXL protocol. Visual acuity (VA), slit-lamp examination, refraction, pentacam reading of keratometry (K), corneal thickness, and thinnest location pachymetry were noted. Cases were followed up on days 1, 5, and at 1st, 3rd, 6th, and 12th-month post procedure.
Results:
Statistically, significant improvement of the mean aided VA, K, and mean corneal astigmatism (p < 0.0001) was noted. Mean Kmax reading reduced from 55.5 ± 5.64 (47.4-70.4) diopter (D) preoperatively to 54.41 ± 5.51 (46-68.3) D at 12 months postaccelerated CXL. Two cases had progression. Complications encountered were sterile infiltrate and persistent haze.
Conclusion:
Accelerated CXL is effective and efficacious in pediatric KC.
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