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Updated: Jul 30, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ

Jun Yong Choi1,2,3, Yoshihiko Noguchi1, James M Alburger1

  • 1Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, United States.

Journal of Medicinal Chemistry
|May 19, 2023
PubMed
Summary

Researchers developed a novel inhibitor, SR-4133, that selectively targets Casein Kinase 1 epsilon (CK1ε). This breakthrough offers potential for treating bladder cancer by inhibiting CK1ε activity and downstream signaling pathways.

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