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EPOR activation attenuates colitis via enhancing LC3B-dependent apoptotic cell clearance

Xue Liu1,2, Ling-Yuan Zhang1, Yu-Ge Zhang1

  • 1School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.

Immunology
|May 19, 2023
PubMed
Summary

Erythropoietin receptor (EPOR) activation in macrophages alleviates colitis by enhancing apoptotic cell clearance, likely through LC3B-associated phagocytosis (LAP). This discovery offers a new therapeutic target for inflammatory bowel disease (IBD).

Keywords:
EPORLC3B‐associated phagocytosisexperimental colitismacrophage

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