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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

819

Variability in Swallowed Topical Corticosteroid Practice Patterns for Treatment of Pediatric Eosinophilic Esophagitis

Erin Phillips Syverson1,2, Michelle Tobin3, Tiffany Patton4

  • 1From the Boston Children's Hospital, Boston, MA.

Journal of Pediatric Gastroenterology and Nutrition
|May 19, 2023
PubMed

Insights

Pediatric gastroenterologists show varied prescribing practices for swallowed topical corticosteroids (STC) in eosinophilic esophagitis (EoE). Oral viscous budesonide is a common choice, but preparation and barriers need standardization.

Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Eosinophilic esophagitis (EoE) treatment lacks standardized swallowed topical corticosteroids (STC).
  • Understanding current STC prescribing practices is crucial for developing guidelines.

Purpose of the Study:

  • To investigate the prescribing habits of pediatric gastroenterologists regarding STC for EoE.
  • To identify common STC formulations, vehicles, and barriers to use.

Main Methods:

  • A 12-question survey was distributed to pediatric gastroenterologists in the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Eosinophilic Gastrointestinal Disease Special Interest Group.
  • Responses from 42 physicians were analyzed to determine STC prescribing patterns.

Main Results:

  • Oral viscous budesonide (OVB) was the preferred STC for 74% of respondents, particularly in younger children.
  • Fluticasone propionate was favored for adolescents (13-18 years).
  • Nineteen different mixing vehicles were reported for OVB; insurance, cost, and compliance were key barriers.

Conclusions:

  • Significant variability exists in STC prescribing for EoE among pediatric gastroenterologists.
  • The findings underscore an urgent need for standardized STC treatment protocols in EoE management.

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