The potential of regulatory T cell-based therapies for alopecia areata

Cytotoxic T lymphocyte has been a concern for the etiopathogenesis of alopecia areata (AA), some recent evidence suggests that the regulatory T (T_reg) cell deficiency is also a contributing factor. In the lesional scalp of AA, T_reg cells residing in the follicles are impaired, leading to dysregulated local immunity and hair follicle (HF) regeneration disorders. New strategies are emerging to modulate T_reg cells' number and function for autoimmune diseases. There is much interest to boost T_reg cells in AA patients to suppress the abnormal autoimmunity of HF and stimulate hair regeneration. With few satisfactory therapeutic regimens available for AA, T_reg cell-based therapies could be the way forward. Specifically, CAR-T_reg cells and novel formulations of low-dose IL-2 are the alternatives.