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07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
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Basophils beyond allergic and parasitic diseases
Remo Poto1,2, Stefania Loffredo1,2,3,4, Gianni Marone1,2,3,4
1Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Frontiers in Immunology
|May 19, 2023
Summary
Basophils, similar to mast cells, are key in allergies. Emerging research reveals their diverse roles beyond allergies, including protective and harmful functions in various non-allergic diseases.
Area of Science:
- Immunology
- Cell Biology
Background:
- Basophils share FcεRI-αβγ2 receptor and mediator release with mast cells, questioning their unique roles.
- Unlike tissue-resident mast cells, basophils circulate and infiltrate tissues during inflammation.
Purpose of the Study:
- To review the dichotomous roles of basophils in both allergic and non-allergic disorders.
- To explore emerging evidence of basophil involvement in pathologies beyond allergy.
Main Methods:
- Literature review of recent findings on basophil functions.
- Analysis of basophil involvement in various disease models and human pathologies.
Main Results:
- Basophils are implicated in non-allergic diseases like myocardial infarction, autoimmunity, COPD, fibrosis, and cancer.
- Evidence suggests basophils play protective roles in parasitic infections and wound healing.
- Human and mouse basophils are significant sources of Interleukin-4 (IL-4) and Interleukin-13 (IL-13).
Conclusions:
- Basophils exhibit dual roles, contributing to both protection and harm in a spectrum of non-allergic conditions.
- Further research is needed to clarify the precise role of basophils in pathology versus homeostasis.
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