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Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment
Xingran Liu1,2, Yihao Liu1,2, Lei Qiang3
1Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of Tissue Engineering
|May 19, 2023
Summary
Multifunctional 3D-printed bioceramic scaffolds offer new hope for treating osteosarcoma (bone cancer) in children and teens. These advanced scaffolds combine bone regeneration with novel anti-tumor therapies to improve patient outcomes.
Area of Science:
- Biomaterials Science
- Oncology
- Regenerative Medicine
- 3D Printing Technology
Background:
- Osteosarcoma is a primary bone cancer predominantly affecting children and adolescents.
- Current treatments face challenges with bone defects, tumor recurrence, and metastasis, impacting patient quality of life.
- Conventional bioceramic scaffolds primarily support bone regeneration (osteogenesis).
Purpose of the Study:
- To review the potential of multifunctional 3D-printed bioceramic scaffolds for osteosarcoma treatment.
- To explore advanced anti-tumor strategies integrated into patient-specific scaffolds.
- To provide a future outlook on these promising therapeutic platforms.
Main Methods:
- Review of existing literature on osteosarcoma, 3D-printed bioceramic scaffolds, and various anti-tumor therapies.
- Integration of patient-specific design enabled by 3D printing technology.
- Incorporation of functional agents for combined osteogenesis and anti-tumor effects.
Main Results:
- Advances in 3D printing and materials science allow for patient-specific scaffolds with enhanced functionalities.
- Novel anti-tumor therapies (photothermal, magnetothermal, chemo-, gas, and photodynamic) can be loaded into scaffolds.
- These strategies demonstrate potential in overcoming drug resistance and inhibiting osteosarcoma metastasis.
Conclusions:
- Multifunctional 3D-printed bioceramic scaffolds represent a significant advancement in osteosarcoma treatment.
- The combination of osteogenesis and targeted anti-tumor therapies offers a promising approach for refractory cases.
- These innovative scaffolds hold excellent potential for improving the quality of life for osteosarcoma patients.
