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Updated: Jul 29, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Lipid metabolism in tumor immunology and immunotherapy
Lisa K Duong1, Halil Ibrahim Corbali1,2, Thomas S Riad1
1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Abstract:
Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.
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