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The key role of microRNA-766 in the cancer development

Jitendra Gupta1, Hussein Riyadh Abdul Kareem Al-Hetty2, Murtadha Sh Aswood3

  • 1Institute of Pharmaceutical Research, GLA University, Mathura, India.

Frontiers in Oncology
|May 19, 2023
PubMed

Insights

MicroRNA-766 (miR-766) is overexpressed in cancers, promoting tumor growth and therapeutic resistance. Targeting miR-766 offers potential for novel cancer treatments and diagnostics.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Cancer arises from genetic defects affecting RNA, impacting drug efficacy.
  • MicroRNAs (miRNAs) regulate vital cellular processes like cell division and apoptosis, often disrupted in cancer.
  • miR-766, a conserved miRNA, is overexpressed in malignancies and linked to disease progression.

Purpose of the Study:

  • To review evidence linking miR-766 to cancer development and treatment resistance.
  • To explore the potential of miR-766 as a therapeutic target, diagnostic biomarker, and prognostic indicator in cancer.

Main Methods:

  • Literature review and evidence synthesis.
  • Analysis of miR-766 expression patterns in various cancers.
  • Discussion of miR-766's role in cancer pathogenesis and therapeutic resistance mechanisms.

Main Results:

  • miR-766 overexpression is associated with multiple cancer types.
  • miR-766 contributes to cancer development and promotes resistance to therapies.
  • Aberrant miR-766 expression correlates with pathological and physiological changes in cancer.

Conclusions:

  • miR-766 plays a significant role in cancer initiation and progression.
  • miR-766 is implicated in therapeutic resistance, diminishing treatment effectiveness.
  • miR-766 holds promise as a biomarker and therapeutic target for innovative cancer strategies.
Keywords:
biomarkercancerdrug resistancemiR-766microRNA

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