Related Experiment Video
Updated: Feb 1, 2026
10:53
Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
Published on: February 26, 2018
48.6K
Nicardipine: protection against brain hypoxia
Drugs Under Experimental and Clinical Research
|January 1, 1986
Summary
Nicardipine, a vasodilator, improved brain function during oxygen deprivation. This calcium antagonist enhanced survival and electrical signals, suggesting protective effects via increased cerebral blood flow.
Area of Science:
- Pharmacology
- Neuroscience
- Cardiovascular Research
Background:
- Nicardipine is a vasodilator and calcium antagonist.
- Hypoxia poses a significant threat to central nervous system function.
- Understanding antihypoxic agents is crucial for neuroprotection.
Purpose of the Study:
- To evaluate the antihypoxic activity of nicardipine on the central nervous system.
- To investigate nicardipine's effects on survival and brain electrical activity under hypoxic conditions.
Main Methods:
- Utilized hypobaric hypoxia models to induce oxygen deprivation.
- Assessed electrocorticogram alterations during asphyxic anoxia.
- Quantified changes in survival time and electrical signal impairment.
Main Results:
- Nicardipine significantly improved survival time in hypoxic models.
- The drug mitigated electrical signal impairment caused by asphyxic anoxia.
- Nicardipine demonstrated a protective effect against central nervous system hypoxia.
Conclusions:
- Nicardipine exhibits significant antihypoxic properties on the central nervous system.
- The observed brain protection is likely mediated by enhanced cerebral blood supply.
- Further research into nicardipine for hypoxia-related conditions is warranted.
More Related Videos
12:02Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
16.5K
11:02In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model
Published on: October 3, 2011
20.3K
Related Concept Videos
01:27Protecting Self-Esteem
210
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
210
01:23Hypoxia
2.1K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.1K
02:31Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
01:16Zones of Protection
794
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
794
01:23Radial System Protection
443
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
443
01:27Line Protection with Impedance Relays
454
Coordinating time-delay overcurrent relays in complex radial systems and directional overcurrent relays in multi-source transmission loops can be challenging. Impedance relays address these issues by responding to the voltage-to-current ratio, specifically measuring the apparent impedance of a line. These relays become more sensitive during faults as current increases and voltage decreases, thereby reducing the apparent impedance.
Under normal conditions, low load currents keep the measured...
Under normal conditions, low load currents keep the measured...
454