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Therapeutic experience with ketoconazole.

E M Difonzo, G M Palleschi, P Vannini

    Drugs Under Experimental and Clinical Research
    |January 1, 1986
    PubMed
    Summary
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    Ketoconazole effectively treated various fungal infections, including dermatophytoses and candidosis, with high cure rates and no significant side effects observed in patients. This antifungal medication proved a reliable option for managing superficial and deep mycoses.

    Area of Science:

    • Mycology
    • Dermatology
    • Infectious Diseases

    Background:

    • Fungal infections pose a significant global health challenge.
    • Ketoconazole is a broad-spectrum antifungal agent.
    • Evaluating ketoconazole's efficacy in diverse mycoses is crucial.

    Purpose of the Study:

    • To assess the therapeutic efficacy of ketoconazole in patients with various fungal infections.
    • To determine cure rates and recurrence incidence following ketoconazole treatment.
    • To monitor for adverse effects associated with ketoconazole therapy.

    Main Methods:

    • A clinical study involving patients diagnosed with dermatophytoses, candidosis, and deep mycoses.
    • Patients were administered oral ketoconazole at standard (200 mg daily) or higher (400 mg daily for five days) doses.

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  • Treatment duration varied until complete clinical cure was achieved, with follow-up assessments.

    • Main Results:

    • Complete cure was achieved in all 45 patients with dermatophytoses within 20-40 days, with no recurrences.
    • Twelve patients with candidosis showed high cure rates, with only one recurrence.
    • Patients with deep mycoses, including cutaneous sporotrichosis, cryptococcosis, and aspergillosis, showed positive responses, with one exception.

    Conclusions:

    • Ketoconazole demonstrates high efficacy as a therapeutic agent for a wide range of fungal infections.
    • The drug is well-tolerated, with no significant adverse effects reported during the study.
    • Ketoconazole is a valuable and effective treatment option for superficial and deep mycoses.