Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia
Satvinder Kaur1, Lynch Nicole1, Yaniv Sela1
1Beth Israel Deaconess Medical Center.
Research Square
|May 19, 2023
Summary
New research identifies Fork head box protein 2 (FoxP2) expressing neurons in the parabrachial nucleus (PBFoxP2) as key regulators of the respiratory response to carbon dioxide (CO2). These neurons are crucial for maintaining breathing during NREM sleep.
Area of Science:
- Neuroscience
- Respiratory Physiology
- Sleep Science
Background:
- Calcitonin gene-related peptide (CGRP) neurons in the external lateral parabrachial nucleus (PBelCGRP) are vital for arousal during hypercapnia but have minimal impact on respiration.
- Vglut2-expressing neurons in the parabrachial eminence (PBel) are essential for both respiratory and arousal responses to elevated CO2 levels.
Conclusions:
- PBFoxP2 neurons are critical for the respiratory response to CO2 during NREM sleep, and their function cannot be fully compensated by other pathways.
- Targeting PBFoxP2 neuron activity in conjunction with PBelCGRP neuron inhibition may offer a therapeutic strategy for sleep apnea, potentially mitigating hypoventilation and EEG arousals.
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