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Updated: Jul 29, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Selective Enhancer Dependencies in MYC -Intact and MYC -Rearranged Germinal Center B-cell Diffuse Large B-cell

Ashwin R Iyer, Aishwarya Gurumurthy, Rohan Kodgule

    Biorxiv : the Preprint Server for Biology
    |May 19, 2023
    PubMed
    Summary

    High MYC expression drives aggressive B-cell lymphoma. Researchers identified a novel MYC enhancer (GCBME-1) crucial for MYC activation in lymphomas without MYC rearrangements, revealing new therapeutic targets.

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