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Updated: Jul 29, 2025
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Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
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Leveraging observational data to identify targeted patient populations for future randomized trials
Daniel V Lazzareschi1, Nicholas Fong1, Romain Pirracchio1
1UCSF: University of California San Francisco.
Research Square
|May 19, 2023
Summary
Pragmatic trials address limitations in generalizability for randomized controlled trials. This study proposes a method to identify patients receiving perioperative albumin, aiding clinical trial design and evaluating albumin
Area of Science:
- Clinical trials methodology
- Perioperative medicine
- Evidence-based practice
Background:
- Randomized controlled trials (RCTs) often lack generalizability.
- Pragmatic trials offer a solution for real-world applicability.
- Intravenous albumin is common in perioperative care without strong evidence.
Conclusions:
- A structured approach is presented for identifying patients for perioperative albumin trials.
- This method aims to improve the generalizability and relevance of trial findings.
- Optimizing patient selection is crucial for evaluating albumin's role in perioperative care.
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