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Tumor budding in gastric cancer
1Department of Gastric Surgery, Sichuan Cancer Hospital, Chengdu 610041, Sichuan Province, China.
World Journal of Gastrointestinal Surgery
|May 19, 2023
Summary
Tumor budding (TB) is a promising prognostic biomarker in gastric cancer, offering better patient classification than the traditional TNM staging system. This review provides a comprehensive overview of TB in gastric cancer.
Area of Science:
- Oncology
- Cancer Biology
- Pathology
Background:
- The Tumor, Nodes, Metastasis (TNM) staging system is the standard for solid tumor classification but has limitations.
- Prognostic heterogeneity within TNM stages necessitates alternative biomarkers.
- Tumor budding (TB) has shown success in colorectal cancer and is gaining attention in gastric cancer.
Purpose of the Study:
- To provide a holistic overview of tumor budding (TB) in gastric cancer.
- To highlight TB as a promising prognostic biomarker for gastric cancer.
- To discuss the molecular and biological aspects of TB in gastric cancer.
Main Methods:
- Literature review of studies on tumor budding in gastric cancer.
- Analysis of existing data on TB as a prognostic marker.
- Synthesis of molecular and biological insights into TB in gastric cancer.
Main Results:
- Tumor budding (TB) is emerging as a significant prognostic factor in gastric cancer.
- TB can predict disease progression and unfavorable survival outcomes.
- Research is revealing the underlying molecular mechanisms of TB in gastric cancer.
Conclusions:
- Tumor budding (TB) shows potential to improve patient stratification beyond TNM staging in gastric cancer.
- Further research into TB is essential for its clinical application in gastric cancer.
- TB represents a valuable biomarker for predicting gastric cancer prognosis.
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