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Updated: Jul 29, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Systemic osteosclerosis associated with primary bone marrow B-cell lymphoma
Shuji Ozaki1, Tsutomu Iima2, Etsuko Sekimoto1
1Department of Hematology Tokushima Prefecture Central Hospital Tokushima Japan.
Abstract:
Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50-year-old man with severe systemic osteosclerosis associated with primary bone marrow B-cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.
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