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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: Jul 29, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Bioactive peptides for anticancer therapies.

Yehao Zhang1, Cong Wang1, Wenhui Zhang1

  • 1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu Province, China.

Biomaterials Translational
|May 19, 2023
PubMed
Summary

Anticancer peptides (ACPs) offer a promising alternative to traditional cancer treatments. This review summarizes ACPs

Keywords:
anticancer peptideantimicrobial peptideapoptosisnatural resources

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Area of Science:

  • Biochemistry and Molecular Biology
  • Pharmacology and Toxicology
  • Oncology

Background:

  • Cancer remains a significant global public health challenge.
  • Conventional cancer therapies (surgery, radiotherapy, chemotherapy) face limitations including side effects and multidrug resistance.
  • There is a growing need for novel therapeutic strategies with improved efficacy and reduced toxicity.

Purpose of the Study:

  • To review the classification, properties, and sources of anticancer peptides (ACPs).
  • To elucidate the mechanisms of action and membrane disruption by ACPs.
  • To provide insights for designing ACPs with enhanced specificity and reduced side effects.

Main Methods:

  • Comprehensive literature review of studies on anticancer peptides.
  • Analysis of existing data on ACP classification, properties, and natural sources.
  • Examination of research on ACP mechanisms, including membrane disruption.

Main Results:

  • Anticancer peptides (ACPs), derived from natural or modified sources, exhibit significant potential as therapeutic and diagnostic agents.
  • ACPs demonstrate high efficacy in inducing cancer cell death through various mechanisms, including membrane disruption.
  • Several ACPs have progressed to clinical trials as drugs and vaccines.

Conclusions:

  • Anticancer peptides represent a promising class of novel therapeutic agents for cancer treatment.
  • Their unique advantages over conventional therapies include high efficacy and potential for targeted action.
  • Further research and development of ACPs could lead to more effective and safer cancer treatments.