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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Related Experiment Video

Updated: Jul 29, 2025

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling
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Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

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Activity-based protein profiling - finding general solutions to specific problems.

Benjamin F Cravatt1

  • 1The Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037.

Israel Journal of Chemistry
|May 19, 2023
PubMed
Summary
This summary is machine-generated.

This perspective discusses the development and application of activity-based protein profiling (ABPP) technology over 25 years. It highlights the contributions of colleagues to a special issue on innovative science.

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Area of Science:

  • Biochemistry
  • Chemical Biology
  • Proteomics

Background:

  • Activity-based protein profiling (ABPP) is a powerful chemical proteomics technology.
  • The development and application of ABPP have been a major focus for the author's lab for over 25 years.

Purpose of the Study:

  • To provide a retrospective and perspective on the development and application of ABPP technology.
  • To acknowledge and thank colleagues who contributed to a special issue.

Main Methods:

  • Retrospective analysis of the development of ABPP technology.
  • Perspective on the application of ABPP in various scientific fields.

Main Results:

  • The abstract does not contain specific results, as it is a perspective piece.
  • It emphasizes the long-standing commitment to advancing ABPP technology.

Conclusions:

  • The author reflects on the significant journey of ABPP technology.
  • Appreciation is expressed for the collaborative efforts within the scientific community.