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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Updated: Jul 29, 2025

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
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Study on Effects of Sublingual Immunotherapy in Allergic Rhinitis Patients.

Keval Patel1, Nandini Gupta1, Bela J Prajapati1

  • 1Department of OtoRhinoLaryngology Civil Hospital, Ahmedabad, Gujarat India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|May 19, 2023
PubMed
Summary

Sublingual immunotherapy (SLIT) effectively treats allergic rhinitis by improving quality of life and reducing symptom severity. This allergy treatment also lowers IgE levels and medication needs in patients.

Keywords:
Allergic rhinitisSLITSkin prick test

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Area of Science:

  • Immunology
  • Allergology
  • Otolaryngology

Background:

  • Allergic rhinitis is a prevalent allergic condition causing significant discomfort.
  • Pharmacological treatments are standard, but some patients require immunotherapy for refractory symptoms.

Purpose of the Study:

  • To evaluate the clinical efficacy, safety, and tolerability of sublingual immunotherapy (SLIT) in allergic rhinitis patients.
  • To assess the impact of SLIT on quality of life and symptom severity.

Main Methods:

  • A 1-year study involving 40 allergic rhinitis patients with positive skin prick tests.
  • Treatment involved SLIT using a mix of dust mites, tree pollens, grass pollens, and weed pollens.
  • Clinical effects, safety, tolerability, IgE levels, eosinophil counts, and medication requirements were monitored.

Main Results:

  • Significant improvements were observed in quality of life and both nasal and non-nasal symptom severity after 1 year of SLIT.
  • Sublingual immunotherapy led to a reduction in total IgE and absolute eosinophilic count.
  • Patients on SLIT required less medication for symptom control.

Conclusions:

  • Sublingual immunotherapy is a safe and effective treatment option for allergic rhinitis.
  • SLIT demonstrates clinical efficacy in reducing symptoms and improving the quality of life for patients with allergies to multiple allergens.
  • This allergy treatment approach offers a valuable alternative for patients unresponsive to conventional therapies.