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Updated: Jul 29, 2025
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical
Jin Zeng1, Yi Peng1, Dong Wang1
1Department of Spine Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
Abstract:
Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate has not improved significantly in the past 30 years, which brings a heavy burden to patients and society. The high heterogeneity of osteosarcoma leads to the lack of specific targets and poor therapeutic effect. Tumor microenvironment is the focus of current research, and osteosarcoma is closely related to bone microenvironment. Many soluble factors and extracellular matrix secreted by many cells in the bone microenvironment have been shown to affect the occurrence, proliferation, invasion and metastasis of osteosarcoma through a variety of signaling pathways. Therefore, targeting other cells in the bone microenvironment may improve the prognosis of osteosarcoma. The mechanism by which osteosarcoma interacts with other cells in the bone microenvironment has been extensively investigated, but currently developed drugs targeting the bone microenvironment have poor efficacy. Therefore, we review the regulatory effects of major cells and physical and chemical properties in the bone microenvironment on osteosarcoma, focusing on their complex interactions, potential therapeutic strategies and clinical applications, to deepen our understanding of osteosarcoma and the bone microenvironment and provide reference for future treatment. Targeting other cells in the bone microenvironment may provide potential targets for the development of clinical drugs for osteosarcoma and may improve the prognosis of osteosarcoma.
Insights
Osteosarcoma, a deadly bone cancer, has poor survival rates due to its complex nature. Targeting the tumor microenvironment offers new hope for improving osteosarcoma treatment outcomes.
Area of Science:
- Oncology
- Cancer Biology
- Biomedical Research
Background:
- Osteosarcoma is a primary bone cancer with high mortality and stagnant survival rates.
- Its heterogeneity complicates targeted therapies, leading to poor treatment efficacy.
- The tumor microenvironment, particularly the bone microenvironment, significantly influences osteosarcoma progression.
Purpose of the Study:
- To review the regulatory effects of the bone microenvironment on osteosarcoma.
- To explore interactions between osteosarcoma and bone microenvironment cells.
- To identify potential therapeutic strategies targeting the bone microenvironment for osteosarcoma.
Main Methods:
- Literature review of studies on osteosarcoma and bone microenvironment interactions.
- Analysis of soluble factors, extracellular matrix, and cellular components.
- Examination of signaling pathways involved in osteosarcoma progression.
Main Results:
- Bone microenvironment cells and factors critically affect osteosarcoma occurrence, proliferation, invasion, and metastasis.
- Current drugs targeting the bone microenvironment show limited efficacy.
- Complex interactions exist between osteosarcoma and its microenvironment.
Conclusions:
- Targeting cells within the bone microenvironment presents a promising therapeutic avenue for osteosarcoma.
- Further research into these interactions could lead to novel drug development and improved patient prognosis.
- Understanding the bone microenvironment is crucial for advancing osteosarcoma treatment.
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