Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monte Carlo modeling and phantom studies show Cherenkov emission per unit dose during total skin electron therapy is a function of tissue optical properties.

Medical physics·2026
Same author

Giant cell tumor of the pubic bone with concomitant enchondroma: a case report.

Frontiers in medicine·2026
Same author

3D Reactive Oxygen Species Dosimetry in Pleural Photodynamic Therapy: Integration of Macroscopic Kinetic Modeling and Deformable Registration.

Antioxidants (Basel, Switzerland)·2026
Same author

A high-sensitivity fiber-optic F-P hydraulic pressure sensor based on a corrugated diaphragm structure.

The Review of scientific instruments·2026
Same author

Sensitive detection of cancer antigens enabled by user-defined peptide libraries.

Nature biotechnology·2026
Same author

Monte Carlo analysis of light fluence rate distribution in pleural photodynamic therapy: a study of geometric and optical property effects on treatment delivery.

Journal of biomedical optics·2026

Related Experiment Video

Updated: Jul 29, 2025

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points
09:30

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points

Published on: March 2, 2011

15.7K

A Monte Carlo simulation for Moving Light Source in Intracavity PDT.

Evgueni Parilov1, Karl Beeson1, Mary Potasek1

  • 1Simphotek, Inc., 211 Warren St., Newark, NJ 07103.

Proceedings of Spie--The International Society for Optical Engineering
|May 19, 2023
PubMed
Summary

We developed a novel simulation method for intracavity Photodynamic Therapy (PDT) in lung cancer, accurately modeling light delivery with a moving source. This tool enhances treatment precision for better patient outcomes.

Keywords:
Monte CarloPDTcomputational dosimetryintracavity Photodynamic Therapylight doselight transportlung cavitymoving light source

More Related Videos

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.1K
Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy
07:43

Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy

Published on: April 28, 2022

2.8K

Related Experiment Videos

Last Updated: Jul 29, 2025

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points
09:30

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points

Published on: March 2, 2011

15.7K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.1K
Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy
07:43

Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy

Published on: April 28, 2022

2.8K

Area of Science:

  • Medical Physics
  • Oncology
  • Biomedical Engineering

Background:

  • Intracavity Photodynamic Therapy (PDT) requires precise light dose delivery for pleural lung cancer.
  • The large surface area of the pleural cavity necessitates a moving light source for uniform dosimetry.
  • Existing methods lack accurate simulation of light fluence and fluence rate throughout the entire cavity.

Purpose of the Study:

  • To develop and validate a simulation method for modeling light fluence delivery in intracavity PDT using a moving light source.
  • To enhance the accuracy of light dosimetry in complex anatomical spaces like the pleural cavity.
  • To provide a tool for real-time visualization of dose distribution during icav-PDT.

Main Methods:

  • Extended a Monte Carlo (MC) based light propagation solver to support moving light sources.
  • Implemented a method (PEDSy-MC) using GPU CUDA for efficient computation.
  • Validated the simulation against analytic solutions using a life-size lung-shaped phantom with multiple detectors.

Main Results:

  • The PEDSy-MC method accurately simulates light fluence and fluence rate for intracavity PDT.
  • Achieved simulation results within a 5% error of the analytic solution for multiple detectors.
  • Demonstrated rapid computation times (under a minute to minutes) on a GPU-accelerated implementation.
  • Developed a 2D/3D dose-cavity visualization tool for real-time inspection.

Conclusions:

  • The developed simulation method (PEDSy-MC) provides accurate and efficient modeling of light delivery for intracavity PDT.
  • This tool has potential for real-time navigation and dose assessment in clinical applications.
  • The visualization tool will aid ongoing clinical trials at the Perlman School of Medicine (PSM).