Related Experiment Video

Updated: Jul 29, 2025

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

13.8K

Novel targeted drugs for follicular and marginal zone lymphoma: a comprehensive review

Andrea Rivero1,2, Pablo Mozas1,2, Laura Magnano1,2

  • 1Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.

Frontiers in Oncology
|May 19, 2023
PubMed

Insights

New indolent non-Hodgkin lymphoma (iNHL) therapies, including targeted drugs and immunotherapy, offer promising outcomes. These chemotherapy-free options are crucial for older patients with comorbidities, advancing personalized medicine in iNHL treatment.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Indolent non-Hodgkin lymphomas (iNHL) are chronic conditions with long survival but limited curative options.
  • Patients often have comorbidities, complicating treatment decisions.
  • Advances in understanding iNHL biology have spurred the development of novel, often chemotherapy-free, therapies.

Purpose of the Study:

  • To review recent therapeutic advances in follicular and marginal zone lymphoma.
  • To discuss emerging targeted therapies, monoclonal antibodies, and antibody-drug conjugates.
  • To explore immune-directed approaches like bispecific T-cell engagers and CAR T-cell therapy.

Main Methods:

  • Review of recent literature on iNHL therapeutics.
  • Analysis of emerging data on novel drug classes.
  • Perspective on personalized medicine challenges and future directions.

Main Results:

  • Novel therapies include PI3K inhibitors, BTK inhibitors, EZH2 inhibitors, and antibody-drug conjugates.
  • Immune-directed approaches such as lenalidomide combinations, bispecific T-cell engagers, and CAR T-cell therapy show significant promise.
  • These newer treatments can achieve durable responses with manageable toxicities, reducing reliance on chemotherapy.

Conclusions:

  • Significant progress has been made in developing chemotherapy-free treatments for iNHL.
  • Personalized medicine approaches are essential for optimizing treatment selection and sequencing.
  • Novel targeted and immune-based therapies offer improved outcomes and tolerability for iNHL patients.
Keywords:
CAR-T cellsfollicular lymphomaimmunotherapymarginal zone lymphomatargeted therapy

More Related Videos

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

5.5K
Using Optical Tweezers for the Generation of Hybrid Spheroids12:11

Using Optical Tweezers for the Generation of Hybrid Spheroids

Published on: May 30, 2025

474

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.7K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.3K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.7K