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Updated: Jul 29, 2025
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The ITS2 Database
Published on: March 12, 2012
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SH2db, an information system for the SH2 domain
Dávid Bajusz1, Gáspár Pándy-Szekeres1,2, Ágnes Takács1
1Medicinal Chemistry Research Group and National Laboratory for Drug Researchand Development, Research Centre for Natural Sciences, Magyar tudósok krt. 2, 1117 Budapest, Hungary.
Nucleic Acids Research
|May 19, 2023
Summary
Researchers can now access SH2db, a new database and webserver for SH2 domain structures. This resource aids drug discovery by organizing and comparing SH2 domain data.
Area of Science:
- Biochemistry
- Structural Biology
- Bioinformatics
Background:
- SH2 domains mediate phosphotyrosine signaling, crucial in oncological diseases.
- Their conserved structure features pockets for phosphotyrosine and substrate binding.
- Structural databases are vital for drug discovery research.
Purpose of the Study:
- To introduce SH2db, a comprehensive structural database and webserver for SH2 domains.
- To enhance comparability of SH2 domains through a generic residue numbering scheme.
- To provide a centralized resource for SH2 domain sequences and structures.
Main Methods:
- Developed SH2db, a structural database and webserver.
- Implemented a generic residue numbering scheme for SH2 domains.
- Created a structure-based multiple sequence alignment of human SH2 domains using PDB and AlphaFold structures.
Main Results:
- SH2db offers searchable, browsable, and downloadable SH2 domain sequences and structures.
- Includes functions for Pymol session preparation and data charting.
- Provides aligned sequences and structures for 120 human wild-type SH2 domains.
Conclusions:
- SH2db serves as a valuable, one-stop resource for researchers studying SH2 domains.
- Facilitates daily work in SH2 domain research and drug discovery.
- Enhances comparability and accessibility of SH2 domain structural data.
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