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Bromodomain inhibitors and therapeutic applications

Bharath Kumar Gajjela1, Ming-Ming Zhou1

  • 1Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, United States.

Current Opinion in Chemical Biology
|May 19, 2023
PubMed
Summary

New small molecule inhibitors target bromodomain proteins, including BET family members like BRD4, for cancer and inflammatory diseases. Research strategies aim to overcome toxicity challenges for these epigenetic drugs.

Keywords:
BET proteinsBromodomainBromodomain inhibitorsDrug discoveryGene transcription

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