Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

733
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
733

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytarabine-based induction and oral maintenance therapy for a single system with single-site Langerhans cell histiocytosis.

International journal of hematology·2026
Same author

Utility of Integrating Genome-Wide Postmortem Testing into Clinical Autopsy Practice in Pediatrics: A Retrospective, Single-Center Study.

Fetal and pediatric pathology·2026
Same author

Immunohistochemistry-Based Screening for Targetable Kinase Alterations in Non-Langerhans Cell Histiocytosis with Juvenile Xanthogranuloma morphology.

Virchows Archiv : an international journal of pathology·2026
Same author

Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.

Oncology letters·2026
Same author

Coexpression of MYCN and ALK Induces Neuroblastoma-Like Tumors From Human iPS Cell-Derived Cranial Neural Crest Cells.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same author

Intratumoral heterogeneity of MYC status and methylation subtyping in group 3 medulloblastoma: A case report.

Journal of neuropathology and experimental neurology·2025

Related Experiment Video

Updated: Jul 29, 2025

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
07:48

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Published on: May 24, 2016

18.7K

Cardiac mucosa in neonates.

Kaiyo Takubo1, Junko Aida2, Michael Vieth3

  • 1Esophageal Cardiac Glands Investigation Committee, Japan Esophageal Society, Tokyo 130-0012, Japan; Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.

Pathology, Research and Practice
|May 19, 2023
PubMed
Summary

Cardiac mucosa is present in Japanese neonates and infants at birth, regardless of prematurity or parietal cell presence. This finding clarifies the histology of the esophagogastric junction in newborns.

Keywords:
Cardiac mucosa·Oxyntocardiac mucosa·Parietal cells·Barrett’s esophagus·Anti-proton pump antibody

More Related Videos

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
08:16

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Published on: November 5, 2016

7.8K
Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

2.9K

Related Experiment Videos

Last Updated: Jul 29, 2025

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
07:48

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Published on: May 24, 2016

18.7K
Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
08:16

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Published on: November 5, 2016

7.8K
Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

2.9K

Area of Science:

  • Histopathology
  • Neonatal Physiology
  • Gastroenterology

Background:

  • The presence and histology of cardiac mucosa at the esophagogastric junction (EGJ) in neonates at birth remain debated.
  • Clarifying EGJ morphology in newborns is crucial for understanding early gastrointestinal development.

Purpose of the Study:

  • To investigate the morphology of the cardiac mucosa at the EGJ in Japanese neonates and infants.
  • To determine the presence or absence of cardiac mucosa at birth in this population.

Main Methods:

  • A histopathological examination was performed on 43 Japanese neonates and infants (premature and full-term).
  • Specimens were collected from deceased infants aged 1 to 231 days post-birth.

Main Results:

  • Cardiac mucosa, lacking parietal cells, was found in 74% of cases, particularly in full-term neonates within 14 days of birth.
  • Cardiac mucosa with parietal cells was observed in 23% of cases; 2% had columnar-lined esophagus.
  • Mixed squamous and columnar epithelia were present in 51% of EGJ sections.

Conclusions:

  • Cardiac mucosa is confirmed to exist in neonates and infants at birth, irrespective of parietal cell presence (oxyntocardiac mucosa).
  • Both premature and full-term neonates possess cardiac mucosa at the EGJ shortly after birth, similar to Caucasian neonates.