Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical
Billy Wai-Lung Ng1, Tongyang Xu2, Zhihao Guo2
1School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Abstract:
Most human proteins lack small-molecule ligands, rendering these proteins "undruggable." In this issue of Molecular Cell, Lazear et al.1 develop a novel chemical proteomic screening platform and discover new chemical probes targeting previously undruggable protein complexes.
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