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Published on: May 12, 2022
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Ivermectin metabolites reduce Anopheles survival.
Kevin C Kobylinski1,2, Phornpimon Tipthara3, Narenrit Wamaket4,5
1Department of Entomology, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok, 10400, Thailand. kobylinskikevin@yahoo.com.
Scientific Reports
|May 19, 2023
Summary
Ivermectin metabolites, like the parent drug, equally kill mosquitoes. This finding supports ivermectin
Area of Science:
- Medical Entomology
- Parasitology
- Pharmacology
Background:
- Mass drug administration of ivermectin is explored as a tool for malaria elimination.
- Observed mosquito-lethal effects of ivermectin in trials exceed in vitro predictions.
- This suggests ivermectin metabolites may contribute to its vector control efficacy.
Purpose of the Study:
- To investigate the mosquito-lethal effects of primary human ivermectin metabolites.
- To compare the efficacy of ivermectin and its metabolites against key malaria vectors.
Main Methods:
- Synthesized or obtained three major human ivermectin metabolites (M1, M3, M6).
- Mixed ivermectin and metabolites in human blood at various concentrations.
- Fed treated blood to Anopheles dirus and Anopheles minimus mosquitoes, monitoring mortality for 14 days.
- Quantified compound concentrations using liquid chromatography-tandem mass spectrometry.
Main Results:
- No significant differences in lethal concentration (LC50, LC90) between ivermectin and its metabolites for either mosquito species.
- No substantial differences in the time to median mosquito mortality.
- Ivermectin and its major metabolites exhibited equal mosquito-killing rates.
Conclusions:
- Ivermectin metabolites possess a mosquito-lethal effect comparable to the parent compound.
- These metabolites contribute to Anopheles mortality following human ivermectin treatment.
- Supports the role of ivermectin and its metabolites in malaria vector control strategies.
