Mouse primordial germ cells use fibronectin as a substrate for migration

The behavior in vitro of mouse primordial germ cells (PGCs) on different substrates was studied by means of microcinematography. It was observed that for displacement, the PGCs required fibronectin in the substrate and that this glycoprotein was present in vivo in those routes along which the cells moved. It was concluded that fibronectin plays an important role in the migration of the PGCs to the genital crests.