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Updated: Jul 29, 2025
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
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Crosstalk between the mTOR and Hippo pathways
Daichi Honda1, Misako Okumura1,2, Takahiro Chihara1,2
1Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Development, Growth & Differentiation
|May 20, 2023
Summary
The mechanistic target of the rapamycin (mTOR) and Hippo pathways coordinate cell growth and proliferation. This review details their molecular interactions, crucial for regulating tissue growth and nutrient consumption.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Cell behavior is influenced by growth factors, nutrients, and cell density.
- The mTOR pathway regulates cell growth and autophagy, responding to growth factors and nutrients.
- The Hippo pathway inhibits cell proliferation and tissue growth, responding to cell density, DNA damage, and hormones.
Purpose of the Study:
- To review the molecular mechanisms of interaction between the mTOR and Hippo pathways.
- To explore these interactions in mammals and Drosophila.
- To discuss the advantages of this interaction in tissue growth and nutrient consumption.
Main Methods:
- Literature review of contemporary research.
- Analysis of molecular mechanisms.
- Comparative study across species (mammals and Drosophila).
Main Results:
- Components of the mTOR and Hippo pathways have been suggested to interact.
- These interactions are crucial for integrating signals related to cell growth, proliferation, and nutrient status.
- The interplay is essential for maintaining proper cell behavior and tissue homeostasis.
Conclusions:
- The integration of mTOR and Hippo pathways is vital for cellular regulation.
- Understanding these interactions provides insights into tissue growth and nutrient metabolism.
- Further research is needed to fully elucidate the complex regulatory network between these pathways.
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