Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.7K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.7K
The Endocrine System01:29

The Endocrine System

382
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
382
Structures of the Endocrine System00:59

Structures of the Endocrine System

7.8K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
7.8K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

494
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
494
Autoimmune Disorders01:29

Autoimmune Disorders

544
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
544
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multinucleated giant cells in human pancreatic cancer are a distinct macrophage population undergoing a DNA damage response and associated with an aggressive tumor microenvironment.

Cancer immunology research·2026
Same author

Virtual Evaluation of Hematoxylin & Eosin via Digital Pathology Survey (VEED) Project: Results from a Non-Inferiority Study of a Tabs-Based Staining Method.

Diagnostics (Basel, Switzerland)·2026
Same authorSame journal

Molecular Profiling of Digestive Grade 3 Neuroendocrine Tumors Reveals a Shared Molecular Framework with Lower-Grade Tumors, Marked Heterogeneity, and Therapeutic Opportunities.

Endocrine pathology·2026
Same author

Implantation of cancer cells from transoral endoscopic thyroidectomy: a case report.

Gland surgery·2026
Same author

Adult Pancreatoblastoma: A Challenge in the Differential Diagnosis of Pancreatic Neuroendocrine Neoplasms.

Endocrine pathology·2025
Same author

Pathology of adrenal tumours: recent advances.

Histopathology·2025
Same journal

Distinct ALK Expression Patterns Are Associated with Canonical and Noncanonical STRN::ALK Transcript Architectures in Oncocytic Thyroid Neoplasms.

Endocrine pathology·2026
Same journal

Neuroendocrine Tumors of the Gallbladder: A Multicenter Case Series and Systematic Literature Review Indicating Predominantly Non-Aggressive Tumor Behavior and a Common Association with Cholesterol Polyps and Cholesterolosis.

Endocrine pathology·2026
Same journal

Genomic Catastrophe Defines the Evolutionary Trajectory of Adrenocortical Carcinoma.

Endocrine pathology·2026
Same journal

Three-Tier Prognostic Stratification of Lung Carcinoids (NET G1-G2-G3) by Multivariable, Data-Driven Integration of Ki-67 and Mitotic Count.

Endocrine pathology·2026
Same journal

Impact of Molecular Testing on Surgical Decision-Making in Indeterminate Thyroid Nodules: A Global Meta-Analysis Across Test Generations.

Endocrine pathology·2026
See all related articles

Related Experiment Video

Updated: Jul 29, 2025

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

11.7K

Inflammatory and Infectious Disorders in Endocrine Pathology.

Silvia Uccella1,2, Matthias Dottermusch3, Lori Erickson4

  • 1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanule, Milan, Italy. silvia.uccella@gmail.com.

Endocrine Pathology
|May 20, 2023
PubMed
Summary
This summary is machine-generated.

Inflammatory conditions can affect endocrine glands, causing dysfunction and mimicking tumors. Pathologists need to recognize these diverse inflammatory and infectious diseases for accurate diagnosis and patient care.

Keywords:
Autoimmune disordersAutoimmune polyendocrine syndromeEndocrine glandsEndocrine pathologyIgG4-related diseaseImmune check-point inhibitorsInflammatory and infectious disorders

More Related Videos

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

14.7K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.5K

Related Experiment Videos

Last Updated: Jul 29, 2025

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

11.7K
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

14.7K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.5K

Area of Science:

  • Endocrinology
  • Pathology
  • Immunology

Background:

  • Inflammatory conditions frequently involve endocrine glands, leading to dysfunction.
  • These can stem from infections, autoimmune processes, or immune-mediated mechanisms.
  • Inflammation may present as tumor-like lesions, complicating diagnosis.

Purpose of the Study:

  • To review morphological and clinicopathological features of endocrine system inflammation.
  • To guide pathologists in diagnosing infectious and inflammatory disorders of endocrine glands.
  • To cover diverse causes including infections, autoimmune diseases, and IgG4-related disease.

Main Methods:

  • Review of literature on inflammatory and infectious endocrine diseases.
  • Focus on morphological and clinicopathological aspects.
  • Entity-based and organ-based approach for comprehensive coverage.

Main Results:

  • Systemic inflammatory conditions can target the endocrine system.
  • Organ-specific inflammatory disorders are also observed.
  • Accurate diagnosis relies on recognizing varied presentations and utilizing pathological samples.

Conclusions:

  • Pathologists must be aware of pathogenesis, morphology, and differential diagnoses.
  • Understanding these conditions is crucial for clinical management.
  • This review provides a practical guide for diagnosing endocrine inflammation.