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Two-dimensional material-enhanced surface plasmon resonance for antibiotic sensing.

Jisui Tan1, Yangyang Chen1, Jing He2

  • 1State Key Joint Laboratory of ESPC, School of Environment, Tsinghua University, Beijing 100084, China.

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|May 20, 2023
PubMed
Summary

Two-dimensional materials do not enhance intensity-modulated surface plasmon resonance (SPR) sensors. However, optimal nanomaterial properties significantly boost angular-modulated SPR biosensor sensitivity, as shown with MoS2 for sulfonamide detection.

Keywords:
AntibioticsMoS(2)Refractive indexSensitivity enhancementSurface plasmon resonanceTwo-dimensional materials

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Area of Science:

  • Nanotechnology
  • Biosensing
  • Surface Plasmon Resonance (SPR)

Background:

  • Two-dimensional (2D) materials offer unique properties for advanced sensing applications.
  • Surface Plasmon Resonance (SPR) sensors are crucial for environmental, medical, and food safety monitoring.

Purpose of the Study:

  • To systematically evaluate the impact of 2D materials on the sensitivity of gold (Au) chip SPR sensors.
  • To determine optimal material properties for enhancing SPR sensor performance.

Main Methods:

  • Investigated the effect of 2D material's real and imaginary refractive index (RI) and thickness on SPR sensor sensitivity.
  • Utilized angular modulation SPR sensing.
  • Developed a MoS2-enhanced SPR biosensor for sulfonamide detection using an indirect competitive immunoassay.

Main Results:

  • 2D materials do not improve the sensitivity of intensity-modulated SPR sensors.
  • Optimal real part of RI (3.5-4.0) and thickness enhance angular-modulated SPR sensitivity.
  • Lower imaginary part of RI and decreasing thickness correlate with higher sensitivity.
  • A 5 nm MoS2-enhanced SPR biosensor achieved a sulfonamide detection limit of 0.05 μg/L.

Conclusions:

  • 2D material properties critically influence SPR sensor sensitivity, particularly in angular modulation.
  • The study provides criteria for selecting 2D materials to optimize SPR biosensing.
  • MoS2-based SPR biosensors demonstrate significant potential for highly sensitive detection of contaminants like sulfonamides.