Pregnancy in primary immunodeficiency diseases: The PREPI study

Area of Science:

• Immunology
• Reproductive Medicine
• Rare Diseases

Background:

• Primary immunodeficiencies (PID) are rare genetic disorders affecting the immune system.
• Improved medical management has increased survival rates for PID patients.
• Limited data exists on pregnancy outcomes for women with PID.

Purpose of the Study:

• To investigate pregnancy outcomes in women diagnosed with primary immunodeficiencies.
• To identify factors influencing pregnancy course and neonatal outcomes in this population.

Main Methods:

• Retrospective monocentric study involving 93 women with PID.
• Data collected via questionnaires and medical records from a national registry.
• Analysis of PID characteristics, pregnancy events, and neonatal data.

Main Results:

• 69% of 222 pregnancies resulted in live births, with 3% severe preterm births.
• History of severe infection was linked to a higher risk of fetal loss or termination (aOR 0.28).
• Only 59% of pregnancies received optimal anti-infective prophylaxis; severe infections were rare (1%).

Conclusions:

• Pregnancy is feasible for women with various types of PID.
• Increased prematurity and infection history are associated with adverse pregnancy outcomes.
• Enhanced and adjusted antenatal care is crucial for women with PID.