Thermoreversible and tunable supramolecular hydrogels based on chitosan and metal cations

A new thermoreversible and tunable hydrogel CS-M with high water content prepared by metal cation (M = Cu²⁺, Zn²⁺, Cd²⁺ and Ni²⁺) and chitosan (CS) was reported. The influence of metal cations on the thermosensitive gelation of CS-M systems were studied. All prepared CS-M systems were in the transparent and stable sol state and could become the gel state at gelation temperature (T_g). These systems after gelation could recover to its original sol state at low temperature. CS-Cu hydrogel was mainly investigated and characterized due to its large T_g scale (32-80 °C), appropriate pH range (4.0-4.6) and low Cu²⁺ concentration. The result showed that the T_g range was influenced and could be tuned by adjusting Cu²⁺ concentration and system pH within an appropriate range. The influence of anions (Cl^-, NO3^- and Ac^-) in cupric salts in the CS-Cu system was also investigated. Scale application as heat insulation window was investigated outdoors. The different supramolecular interactions of the -NH₂ group in chitosan at different temperatures were proposed to dominate the thermoreversible process of CS-Cu hydrogel.