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Updated: Jul 29, 2025
Quasi-metagenomic Analysis of Salmonella from Food and Environmental Samples
Published on: October 25, 2018
Salmonella Durban meningitis: case report and genomics study
Christelle Nanga Diasi1,2, Pieter-Jan Ceyssens3, Alexandra Vodolazkaia4
1Department of Pediatrics, CHC, Clinique MontLégia, Liège, Belgium.
Background:
Bacterial meningitis caused by non-typhoid Salmonella can be a fatal condition which is more common in low and middle-income countries.
Case Presentation:
We report the case of a Salmonella meningitis in a Belgian six-month old male infant. The first clinical examination was reassuring, but after a few hours, his general state deteriorated. A blood test and a lumbar puncture were therefore performed. The cerebrospinal fluid analysis was compatible with a bacterial meningitis which was later identified by the NRC (National Reference Center) as Salmonella enterica serovar Durban.
Conclusions:
In this paper, we present the clinical presentation, genomic typing, and probable sources of infection for an unusually rare serovar of Salmonella. Through an extended genomic analysis, we established its relationship to historical cases with links to Guinea.
Insights
A rare Salmonella meningitis case in an infant highlights the dangers of non-typhoid Salmonella infections. Genomic analysis linked this Salmonella enterica serovar Durban to historical cases, emphasizing global health surveillance needs.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Non-typhoid Salmonella meningitis is a severe, often fatal condition, particularly prevalent in low and middle-income countries.
- Early diagnosis and intervention are critical for managing bacterial meningitis in infants.
Observation:
- A six-month-old Belgian infant presented with symptoms initially thought to be mild but rapidly deteriorated.
- Diagnostic tests, including cerebrospinal fluid analysis, confirmed bacterial meningitis.
- The causative agent was identified as Salmonella enterica serovar Durban by the National Reference Center.
Findings:
- This case represents an unusually rare serovar of Salmonella causing meningitis.
- Genomic typing revealed a connection between this Salmonella Durban strain and historical cases originating from Guinea.
- The study provides detailed clinical presentation and genomic data for this rare serovar.
Implications:
- This case underscores the importance of considering non-typhoid Salmonella in infant meningitis, even in high-income countries.
- Genomic surveillance is crucial for tracking the spread and evolution of rare bacterial pathogens.
- Understanding the origins and transmission patterns of Salmonella serovars can inform public health strategies and outbreak response.
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