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[Tolerance of amoxicillin-clavulanic acid combination in the child]
Insights
Amoxicillin and clavulanic acid combination therapy showed good gastric tolerance in children over 2 years old, with only one case of treatment discontinuation due to mild sickness. This suggests it is a safe option for pediatric infections caused by beta-lactamase producing microorganisms.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacology
- Microbiology
Context:
- Treatment of pediatric infections
- Use of amoxicillin and clavulanic acid
- Management of beta-lactamase producing microorganisms
Purpose:
- To evaluate the efficacy and safety of amoxicillin and clavulanic acid in children
- To assess the gastrointestinal tolerance of the antibiotic combination
- To determine the suitability of this treatment for specific pediatric infections
Summary:
- Forty children over 2 years old received amoxicillin and clavulanic acid for various infections including meningitis, pneumonia, and typhoid fever.
- Nine patients (22.5%) experienced mild, transient sickness, with only one discontinuation (2.5%) due to adverse effects.
- The study highlights the favorable gastric tolerance profile of this antibiotic combination in the pediatric population.
Impact:
- Provides evidence for the safe use of amoxicillin and clavulanic acid in pediatric patients.
- Supports the use of this combination therapy for infections caused by beta-lactamase producing bacteria.
- Informs clinical decisions regarding antibiotic selection in pediatric infectious diseases.
Abstract:
Forty children all aged over 2 years and eutrophic were treated with the combination amoxycillin and clavulanic acid for various infections (twenty-three with meningitis, eleven with bronchial pneumonia, three with typhoid fever, two with lower urinary tract infections and one with ear infection of moderate severity). Nine of these patients had sickness during treatment which was mild and transient in the majority of cases and caused treatment to be stopped in only one case (2.5%). This low level of gastric tolerance should not concern the paediatrician faced with an infection due to (or most likely to be) a beta-lactamase producing micro-organism.