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Natalizumab extended-interval dosing in a real-life setting
Lina Jeantin1, Marine Boudot de la Motte1, Romain Deschamps1
1Neurology department, Hopital Fondation Adolphe de Rothschild, 25-29 rue Manin, Paris, France.
Journal of the Neurological Sciences
|May 21, 2023
Summary
Extending the natalizumab infusion interval from four to six weeks in patients with relapsing multiple sclerosis (RMS) demonstrated comparable safety and efficacy. This change did not increase relapse rates or MRI activity in a real-world setting.
Area of Science:
- Neurology
- Immunology
- Pharmacology
Background:
- Natalizumab is an effective treatment for relapsing multiple sclerosis (RMS).
- Current treatment involves a four-week administration interval.
- Previous studies suggest extending the interval to six weeks may improve safety without compromising efficacy.
Purpose of the Study:
- To evaluate the safety and efficacy of extending the natalizumab dosing interval from four to six weeks in a real-world setting for RMS patients.
Main Methods:
- A monocentric retrospective self-controlled study was conducted.
- Adult RMS patients on a four-week natalizumab interval for at least six months were switched to a six-week interval.
- Outcomes included MS relapse incidence, new MRI lesions, and MRI activity signs, comparing the two dosing periods within the same patients.
Main Results:
- Fifty-seven patients were analyzed.
- No MS relapses occurred during either the four-week or six-week interval periods.
- New MRI lesions were observed in 13.5% of patients during the four-week interval and 3.6% during the six-week interval.
Conclusions:
- Extending the natalizumab dosing interval to six weeks is safe and effective for RMS patients.
- No increase in relapses or MRI activity was observed with the extended interval.
- This real-world data supports the potential for longer interdose intervals in managing RMS.
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