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Contemporary outcomes of open repair of acute complicated type B aortic dissection
Christopher Lau1, Giovanni Jr Soletti1, Kendall M Lawrence2
1Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.
Insights
Open repair for acute complicated type B aortic dissection (ACTBAD) is safe and effective, with outcomes comparable to elective repair. Transferring patients unsuitable for endovascular repair to experienced centers improves outcomes.
Area of Science:
- Cardiovascular Surgery
- Thoracic Aortic Disease
- Aortic Dissection Repair
Background:
- Open repair of acute complicated type B aortic dissection (ACTBAD) is historically a high-risk procedure.
- Endovascular repair is not always feasible for ACTBAD, necessitating open surgical intervention.
Purpose of the Study:
- To analyze the outcomes of open repair for ACTBAD.
- To compare the high-risk ACTBAD cohort with a standard cohort undergoing thoracic or thoracoabdominal aortic aneurysm repair.
- To identify factors associated with major adverse events (MAEs) in this patient population.
Main Methods:
- Retrospective analysis of 926 patients undergoing descending thoracic or thoracoabdominal aortic aneurysm repair from 1997 to 2021.
- Comparison of 75 patients with ACTBAD to 851 patients with other aortic conditions.
- Logistic regression analysis for MAEs, with 5-year survival and reintervention rates calculated.
Main Results:
- The incidence of MAEs (13.3% vs 13.7%) and operative mortality (5.3% vs 4.8%) were similar between ACTBAD and standard cohorts.
- Complications included tracheostomy (8%), spinal cord ischemia (4%), and new dialysis (2.7%).
- No significant difference in 5- and 10-year survival or 10-year reintervention rates between the groups.
Conclusions:
- Open repair of ACTBAD at an experienced center can be performed with low mortality and morbidity.
- Outcomes comparable to elective repair are achievable for high-risk ACTBAD patients.
- Transfer to high-volume centers for open repair is recommended for patients unsuitable for endovascular treatment.
Objective:
Open repair of acute complicated type B aortic dissection (ACTBAD), required when endovascular repair is not possible, is historically considered high-risk. We analyze our experience with this high-risk cohort compared with the standard cohort.
Methods:
We identified consecutive patients undergoing descending thoracic or thoracoabdominal aortic aneurysm (TAAA) repair from 1997 to 2021. Patients with ACTBAD were compared with those having surgery for other reasons. Logistic regression was used to identify associations with major adverse events (MAEs). Five-year survival and competing risk of reintervention were calculated.
Results:
Of 926 patients, 75 (8.1%) had ACTBAD. Indications included rupture (25/75), malperfusion (11/75), rapid expansion (26/75), recurrent pain (12/75), large aneurysm (5/75), and uncontrolled hypertension (1/75). The incidence of MAEs was similar (13.3% [10/75] vs 13.7% [117/851], P = .99). Operative mortality was 5.3% (4/75) vs 4.8% (41/851) (P = .99). Complications included tracheostomy (8%, 6/75), spinal cord ischemia (4%, 3/75), and new dialysis (2.7%, 2/75). Renal impairment, urgent/emergent operation, forced expiratory volume in 1 second ≤50%, and malperfusion were associated with MAEs, but not ACTBAD (odds ratio: 0.48, 95% confidence interval [CI]: [0.20-1.16], P = .1). At 5 and 10 years, there was no difference in survival (65.8% [95% CI: 54.6-79.2] vs 71.3% [95% CI: 67.9-74.9], P = .42, and 47.3% [95% CI: 34.5-64.7] vs 53.7% [95% CI: 49.3-58.4], P = .29, respectively) or 10-year reintervention (12.5% [95% CI: 4.3-25.3] vs 7.1% [95% CI: 4.7-10.1], P = .17, respectively).
Conclusions:
In an experienced center, open repair of ACTBAD can be performed with low rates of operative mortality and morbidity. Outcomes similar to elective repair are achievable even in high-risk patients with ACTBAD. In patients unsuitable for endovascular repair, transfer to a high-volume center experienced in open repair should be considered.
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