Related Experiment Video

Updated: Jul 29, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

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Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline

Jing Tian1, Lan Guo2, Tienju Wang1

  • 1Department of Pharmacology and Toxicology and.

JCI Insight
|May 22, 2023
PubMed
Summary

Elevated LEAP2/ghrelin ratios in older adults correlate with cognitive decline. Restoring this balance in aged mice improved memory and brain health, suggesting a therapeutic target for age-related cognitive impairment.

Keywords:
AgingAlzheimer diseaseG protein–coupled receptorsMemoryNeuroscience

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