Related Experiment Video

Updated: Jul 29, 2025

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Factors Associated With Early Amputation in Patients With Chronic Limb Threatening Ischemia

Nam Yong Cho1, Zachary Tran2, Syed Shahyan Bakhtiyar3

  • 1Cardiovascular Outcomes Research Laboratories, Division of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

The American Surgeon
|May 22, 2023
PubMed

Insights

Early amputation (EA) remains common in chronic limb-threatening ischemia (CLTI) patients. Risk factors for EA include male sex, low income, tissue loss, end-stage renal disease, diabetes, and endovascular procedures.

Area of Science:

  • Vascular Surgery
  • Health Outcomes Research

Background:

  • Chronic limb-threatening ischemia (CLTI) poses significant challenges despite revascularization advancements.
  • Early amputation (EA) rates persist, necessitating further investigation into associated risk factors and outcomes.

Purpose of the Study:

  • To evaluate clinical outcomes of patients with CLTI.
  • To identify factors associated with EA within 90 days of discharge.

Main Methods:

  • Analysis of the 2016-2019 Nationwide Readmission Database for adult CLTI patients undergoing limb salvage (LS).
  • Primary outcome: EA within 90 days. Secondary outcomes: infectious complications, length of stay (LOS), hospitalization cost, and non-home discharge.

Main Results:

  • 10.1% of 103,703 CLTI patients underwent EA within 90 days.
  • Risk factors for EA included male sex, low income, tissue loss, end-stage renal disease, and diabetes.
  • Endovascular limb salvage was associated with higher odds of EA compared to open revascularization (AOR 1.41).

Conclusions:

  • Several modifiable and non-modifiable risk factors are linked to EA in CLTI patients.
  • Findings can inform performance goals and enhance institutional limb salvage programs.
Abstract

Keywords:
ERASminimally invasive surgeryvascular surgery

More Related Videos

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

3.6K
Methods for Acute and Subacute Murine Hindlimb Ischemia07:57

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

16.5K

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
14
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
11
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
20
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
14
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
15
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
398