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Related Experiment Video

Updated: Jul 29, 2025

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
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Thermally Switchable Nanogate Based on Polymer Phase Transition.

Pauline J Kolbeck1,2,3, Dihia Benaoudia4,5, Léa Chazot-Franguiadakis1

  • 1Univ Lyon, ENS de Lyon, CNRS, Laboratoire de Physique, F-69342 Lyon, France.

Nano Letters
|May 22, 2023
PubMed
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This summary is machine-generated.

Researchers created a switchable nanopore using polymer graftings that controls biomolecule transport. This temperature-responsive system offers precise control over DNA and viral capsid translocation for advanced filtration applications.

Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Biological pores exhibit gating properties crucial for filtration and drug processing.
  • Artificial nanopores are being developed to mimic these biological functions for advanced applications.

Purpose of the Study:

  • To engineer a selective and switchable nanopore for controlled macromolecular cargo transport.
  • To utilize polymer graftings within artificial nanopores to regulate biomolecule translocation.

Main Methods:

  • Employing fluorescence microscopy with a zero-mode waveguide setup for single-biomolecule transport measurements.
  • Grafting polymers with a lower critical solution temperature into artificial nanopores to create a temperature-dependent switch.

Main Results:

Keywords:
biomolecule filtrationcoil−globule transitionnanoporethermoresponsive polymerzero-mode waveguide

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  • Demonstrated a switchable nanopore with a sharp, temperature-controlled transition (approximately 1 °C) between open and closed states.
  • Achieved precise control over the transport of DNA and viral capsids through the nanopore.
  • Developed a physical model accurately predicting the transition behavior.

Conclusions:

  • The developed polymer-grafted nanopore acts as a controllable toggle switch for biomolecule transport.
  • This technology holds potential for creating responsive membranes for filtration and drug delivery systems.
  • The findings pave the way for advanced applications in controllable nanopore technology.