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Depression and anxiety among hemophilia patients enrolled in clinical trials: a multi-center cohort study

Zhen Peng1, Xiaoyu Zhu2, Chongwei Wang1

  • 1Drug Clinical Trial Institution, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Annals of Hematology
|May 22, 2023
PubMed

Insights

Hemophilia patients in clinical trials experience significant depression and anxiety. Acquiring medical information and baseline scores on the PHQ-9 and GAD-7 predict these psychological conditions, necessitating early intervention.

Area of Science:

  • Hematology
  • Psychiatry
  • Clinical Trials

Background:

  • Hemophilia patients in clinical trials often face physical and psychological challenges.
  • Anxiety and depression prevalence and risk factors in this population remain understudied.

Purpose of the Study:

  • To assess the impact of depression and anxiety on hemophilia patients in clinical trials.
  • To identify risk factors associated with depression and anxiety in this cohort.

Main Methods:

  • A multi-center, cohort study involving 69 hemophilia patients from January to December 2022.
  • Baseline (T1) risk factor assessment and psychological symptom evaluation.
  • Follow-up evaluation at 3 months (T2) to measure depression and anxiety levels.

Main Results:

  • Moderate-to-severe depression increased from 18.75% at T1 to 43.75% at T2; anxiety increased from 7.81% to 25.00%.
  • Depression worsened in 35.94% and anxiety in 18.75% of patients.
  • Frequent acquisition of medical information (OR 11.378), baseline GAD-7 (OR 1.341), and PHQ-9 (OR 1.465) scores predicted depression and anxiety.

Conclusions:

  • Hemophilia patients in clinical trials exhibit significant levels of anxiety and depression.
  • Medical information acquisition frequency and baseline PHQ-9/GAD-7 scores are key risk factors.
  • Clinical trial participants require education and psychological evaluations for timely intervention.

Keywords:
AnxietyClinical trialDepressionHemophilia

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